Sex Reversal in C57BL/6J XY Mice Caused by Increased Expression of Ovarian Genes and Insufficient Activation of the Testis Determining Pathway

Sex reversal can occur in XY humans with only a single functional WT1 or SF1 allele or a duplication of the chromosome region containing WNT4. In contrast, XY mice with only a single functional Wt1, Sf1, or Wnt4 allele, or mice that over-express Wnt4 from a transgene, reportedly are not sex-reversed...

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Detalles Bibliográficos
Autores principales: Correa, Stephanie M., Washburn, Linda L., Kahlon, Ravi S., Musson, Michelle C., Bouma, Gerrit J., Eicher, Eva M., Albrecht, Kenneth H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320579/
https://www.ncbi.nlm.nih.gov/pubmed/22496664
http://dx.doi.org/10.1371/journal.pgen.1002569

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320579/
https://www.ncbi.nlm.nih.gov/pubmed/22496664
http://dx.doi.org/10.1371/journal.pgen.1002569

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