2′-O Methylation of Internal Adenosine by Flavivirus NS5 Methyltransferase

RNA modification plays an important role in modulating host-pathogen interaction. Flavivirus NS5 protein encodes N-7 and 2′-O methyltransferase activities that are required for the formation of 5′ type I cap (m(7)GpppAm) of viral RNA genome. Here we reported, for the first time, that flavivirus NS5...

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Detalles Bibliográficos
Autores principales: Dong, Hongping, Chang, David C., Hua, Maggie Ho Chia, Lim, Siew Pheng, Chionh, Yok Hian, Hia, Fabian, Lee, Yie Hou, Kukkaro, Petra, Lok, Shee-Mei, Dedon, Peter C., Shi, Pei-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320599/
https://www.ncbi.nlm.nih.gov/pubmed/22496660
http://dx.doi.org/10.1371/journal.ppat.1002642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320599/
https://www.ncbi.nlm.nih.gov/pubmed/22496660
http://dx.doi.org/10.1371/journal.ppat.1002642

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