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In Vitro and In Vivo Antagonism of a G Protein-Coupled Receptor (S1P(3)) with a Novel Blocking Monoclonal Antibody
BACKGROUND: S1P(3) is a lipid-activated G protein-couple receptor (GPCR) that has been implicated in the pathological processes of a number of diseases, including sepsis and cancer. Currently, there are no available high-affinity, subtype-selective drug compounds that can block activation of S1P(3)....
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320623/ https://www.ncbi.nlm.nih.gov/pubmed/22496900 http://dx.doi.org/10.1371/journal.pone.0035129 |