Cargando…

In Vitro and In Vivo Antagonism of a G Protein-Coupled Receptor (S1P(3)) with a Novel Blocking Monoclonal Antibody

BACKGROUND: S1P(3) is a lipid-activated G protein-couple receptor (GPCR) that has been implicated in the pathological processes of a number of diseases, including sepsis and cancer. Currently, there are no available high-affinity, subtype-selective drug compounds that can block activation of S1P(3)....

Descripción completa

Detalles Bibliográficos
Autores principales:	Harris, Greg L., Creason, Michael B., Brulte, Greg B., Herr, Deron R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320623/ https://www.ncbi.nlm.nih.gov/pubmed/22496900 http://dx.doi.org/10.1371/journal.pone.0035129

Ejemplares similares

Identification of Sphingolipid Metabolites That Induce Obesity via Misregulation of Appetite, Caloric Intake and Fat Storage in Drosophila
por: Walls, Stanley M., et al.
Publicado: (2013)

New monoclonal antibodies that recognize an unglycosylated, conserved, extracellular region of CD44 in vitro and in vivo, and can block tumorigenesis
por: Lusche, Daniel F., et al.
Publicado: (2021)

Brief Report - Monoclonal Antibodies Illustrate the Difficulties in Measuring Blocking TSH Receptor Antibodies
por: Davies, Terry F., et al.
Publicado: (2022)

Mas‐related G protein‐coupled receptor type D antagonism improves portal hypertension in cirrhotic rats
por: Gunarathne, Lakmie S., et al.
Publicado: (2022)

Monoclonal antibody to murine PECAM-1 (CD31) blocks acute inflammation in vivo
Publicado: (1994)

In vivo inhibition of the antibody response by a complement receptor- specific monoclonal antibody
Publicado: (1990)

Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity
por: Corbin, John A., et al.
Publicado: (2014)

Commentary: Brief report - Monoclonal antibodies illustrate the difficulties in measuring blocking TSH receptor antibodies
por: Olivo, Paul D., et al.
Publicado: (2022)

Effect of variable domain charge on in vitro and in vivo disposition of monoclonal antibodies
por: Liu, Shufang, et al.
Publicado: (2021)

The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor
por: Bosma, Reggie, et al.
Publicado: (2017)

Human-IgG-Neutralizing Monoclonal Antibodies Block the SARS-CoV-2 Infection
por: Wan, Jinkai, et al.
Publicado: (2020)

A novel monoclonal antibody KMP1 has potential antitumor activity of bladder cancer by blocking CD44 in vivo and in vitro
por: Chen, Yujin, et al.
Publicado: (2018)

The role of G-protein-coupled membrane estrogen receptor in mouse Leydig cell function—in vivo and in vitro evaluation
por: Kotula-Balak, M., et al.
Publicado: (2018)

In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies
por: Patel, Ami, et al.
Publicado: (2020)

Delivering Monoclonal Antibody Infusions to Novel Outpatient Settings
por: Minnich, Amy, et al.
Publicado: (2022)

Novel anti-HER2 monoclonal antibodies: synergy and antagonism with tumor necrosis factor-α
por: Ceran, Ceyhan, et al.
Publicado: (2012)

In vitro and in vivo anticancer efficacy of unconjugated humanised anti-CEA monoclonal antibodies
por: Blumenthal, R D, et al.
Publicado: (2008)

Escape From Monoclonal Antibody Neutralization Affects Henipavirus Fitness In Vitro and In Vivo
por: Borisevich, Viktoriya, et al.
Publicado: (2016)

In vitro and in vivo properties of a fully human IgG1 monoclonal antibody that combats multidrug resistant Pseudomonas aeruginosa
por: ADAWI, AZMI, et al.
Publicado: (2012)

Assessment of G Protein-Coupled Oestrogen Receptor Expression in Normal and Neoplastic Human Tissues Using a Novel Rabbit Monoclonal Antibody
por: Bubb, Maria, et al.
Publicado: (2022)

Monoclonal Antibodies to the Thyrotropin Receptor
por: Ando, Takao, et al.
Publicado: (2005)

Systematic generation of in vivo G protein-coupled receptor mutants in the rat
por: van Boxtel, R, et al.
Publicado: (2011)

Correction to: In Vivo Delivery of Nucleic Acid-Encoded Monoclonal Antibodies
por: Patel, Ami, et al.
Publicado: (2020)

Reply: In vitro and in vivo anticancer efficacy of unconjugated humanised anti-CEA monoclonal antibodies
por: Ashraf, S Q, et al.
Publicado: (2008)

Generation of Monoclonal Antibodies against Immunoglobulin Proteins of the Domestic Ferret (Mustela putorius furo)
por: Kirchenbaum, Greg A., et al.
Publicado: (2017)

Glutamatergic Dysbalance and Oxidative Stress in In Vivo and In Vitro Models of Psychosis Based on Chronic NMDA Receptor Antagonism
por: Genius, Just, et al.
Publicado: (2013)

Endothelin A Receptor Antagonism Enhances Inhibitory Effects of Anti-Ganglioside GD2 Monoclonal Antibody on Invasiveness and Viability of Human Osteosarcoma Cells
por: Liu, Bo, et al.
Publicado: (2014)

Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo
por: Lund, Ida K., et al.
Publicado: (2012)

Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro and inflammatory cell recruitment in vivo
Publicado: (1987)

An in vitro methodology for discovering broadly-neutralizing monoclonal antibodies
por: Ahmadi, Shirin, et al.
Publicado: (2020)

A monoclonal antibody that blocks adhesion of Chlamydomonas mt+ gametes
Publicado: (1986)

Structural and functional characterization of a monoclonal antibody blocking TIGIT
por: Jeong, Bo-Seong, et al.
Publicado: (2022)

Toll-like receptor 9 antagonizes antibody affinity maturation
por: Akkaya, Munir, et al.
Publicado: (2018)

Engineering therapeutic antibodies targeting G-protein–coupled receptors
por: Jo, Migyeong, et al.
Publicado: (2016)

Quantitative circular flow immunoassays with trained object recognition to detect antibodies to SARS-CoV-2 membrane glycoprotein
por: Huang, Ryan Yuki, et al.
Publicado: (2021)

The activation of G protein-coupled receptor 30 (GPR30) inhibits proliferation of estrogen receptor-negative breast cancer cells in vitro and in vivo
por: Wei, W, et al.
Publicado: (2014)

Negative correlation between the conversion of thyrotropin receptor-bound blocking type thyrotropin receptor antibody to the stimulating type by anti-human IgG antibodies and the biological activity of blocking type thyrotropin receptor antibody.
por: Cho, B. Y., et al.
Publicado: (1993)

Functional Analysis of a Novel Complement C5a Receptor 1-Blocking Monoclonal Antibody
por: Cyranka, Leon, et al.
Publicado: (2023)

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm
por: de Vor, Lisanne, et al.
Publicado: (2022)

Interferon-α/β and Anti-Fibroblast Growth Factor Receptor 1 Monoclonal Antibody Suppress Hepatic Cancer Cells In Vitro and In Vivo
por: Sasaki, Shigeru, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_7120uufkq90jtss64hg4uhvfqm