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The Impact of Imputation on Meta-Analysis of Genome-Wide Association Studies

Genotype imputation is often used in the meta-analysis of genome-wide association studies (GWAS), for combining data from different studies and/or genotyping platforms, in order to improve the ability for detecting disease variants with small to moderate effects. However, how genotype imputation aff...

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Detalles Bibliográficos
Autores principales: Li, Jian, Guo, Yan-fang, Pei, Yufang, Deng, Hong-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320624/
https://www.ncbi.nlm.nih.gov/pubmed/22496814
http://dx.doi.org/10.1371/journal.pone.0034486