Molecular Dynamics Simulation Study and Hybrid Pharmacophore Model Development in Human LTA4H Inhibitor Design

Human leukotriene A4 hydrolase (hLTA4H) is a bi-functional enzyme catalyzes the hydrolase and aminopeptidase functions upon the fatty acid and peptide substrates, respectively, utilizing the same but overlapping binding site. Particularly the hydrolase function of this enzyme catalyzes the rate-limi...

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Detalles Bibliográficos
Autores principales: Thangapandian, Sundarapandian, John, Shalini, Arooj, Mahreen, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320645/
https://www.ncbi.nlm.nih.gov/pubmed/22496831
http://dx.doi.org/10.1371/journal.pone.0034593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320645/
https://www.ncbi.nlm.nih.gov/pubmed/22496831
http://dx.doi.org/10.1371/journal.pone.0034593

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