Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling

The discoidin domain receptors, DDR1 and DDR2, are constitutively dimeric receptor tyrosine kinases that are activated by triple-helical collagen. Aberrant DDR signaling contributes to several human pathologies, including many cancers. We have generated monoclonal antibodies (mAbs) that inhibit DDR1...

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Detalles Bibliográficos
Autores principales: Carafoli, Federico, Mayer, Marie Cathrin, Shiraishi, Kazushige, Pecheva, Mira Anguelova, Chan, Lai Yi, Nan, Ruodan, Leitinger, Birgit, Hohenester, Erhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320712/
https://www.ncbi.nlm.nih.gov/pubmed/22483115
http://dx.doi.org/10.1016/j.str.2012.02.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320712/
https://www.ncbi.nlm.nih.gov/pubmed/22483115
http://dx.doi.org/10.1016/j.str.2012.02.011

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