Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis

BACKGROUND: Amyotrophic lateral sclerosis (ALS) is incurable and characterized by progressive paralysis of the muscles of the limbs, speech and swallowing, and respiration due to the progressive degeneration of voluntary motor neurons. Clinically indistinguishable ALS can be caused by genetic mutati...

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Detalles Bibliográficos
Autores principales: Pokrishevsky, Edward, Grad, Leslie I., Yousefi, Masoud, Wang, Jing, Mackenzie, Ian R., Cashman, Neil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320864/
https://www.ncbi.nlm.nih.gov/pubmed/22493728
http://dx.doi.org/10.1371/journal.pone.0035050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320864/
https://www.ncbi.nlm.nih.gov/pubmed/22493728
http://dx.doi.org/10.1371/journal.pone.0035050

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