HIV/Simian Immunodeficiency Virus (SIV) Accessory Virulence Factor Vpx Loads the Host Cell Restriction Factor SAMHD1 onto the E3 Ubiquitin Ligase Complex CRL4(DCAF1)

The sterile alpha motif and HD domain-containing protein-1 (SAMHD1) inhibits infection of myeloid cells by human and related primate immunodeficiency viruses (HIV and SIV). This potent inhibition is counteracted by the Vpx accessory virulence factor of HIV-2/SIVsm viruses, which targets SAMHD1 for p...

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Detalles Bibliográficos
Autores principales: Ahn, Jinwoo, Hao, Caili, Yan, Junpeng, DeLucia, Maria, Mehrens, Jennifer, Wang, Chuanping, Gronenborn, Angela M., Skowronski, Jacek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321004/
https://www.ncbi.nlm.nih.gov/pubmed/22362772
http://dx.doi.org/10.1074/jbc.M112.340711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321004/
https://www.ncbi.nlm.nih.gov/pubmed/22362772
http://dx.doi.org/10.1074/jbc.M112.340711

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