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Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation
Chromosomal DNA replication requires one daughter strand—the lagging strand—to be synthesised as a series of discontinuous, RNA-primed Okazaki fragments, which must subsequently be matured into a single covalent DNA strand. Here, we describe the reconstitution of Okazaki fragment maturation in vitro...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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European Molecular Biology Organization
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321178/ https://www.ncbi.nlm.nih.gov/pubmed/22307085 http://dx.doi.org/10.1038/emboj.2012.12 |