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O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

Transforming growth factor (TGF)-β-activated kinase 1 (TAK1) is a key serine/threonine protein kinase that mediates signals transduced by pro-inflammatory cytokines such as transforming growth factor-β, tumour necrosis factor (TNF), interleukin-1 (IL-1) and wnt family ligands. TAK1 is found in compl...

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Detalles Bibliográficos
Autores principales: Pathak, Shalini, Borodkin, Vladimir S, Albarbarawi, Osama, Campbell, David G, Ibrahim, Adel, van Aalten, Daan MF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321193/
https://www.ncbi.nlm.nih.gov/pubmed/22307082
http://dx.doi.org/10.1038/emboj.2012.8