Cargando…

Dissecting the role of glutathione biosynthesis in Plasmodium falciparum

Glutathione (γ-glutamylcysteinyl-glycine, GSH) has vital functions as thiol redox buffer and cofactor of antioxidant and detoxification enzymes. Plasmodium falciparum possesses a functional GSH biosynthesis pathway and contains mM concentrations of the tripeptide. It was impossible to delete in P. f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patzewitz, Eva-Maria, Wong, Eleanor H, Müller, Sylke
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2012
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321222/ https://www.ncbi.nlm.nih.gov/pubmed/22151036 http://dx.doi.org/10.1111/j.1365-2958.2011.07933.x

Ejemplares similares

Glutathione biosynthesis and metabolism in Plasmodium falciparum
por: Patzewitz, Eva-Maria, et al.
Publicado: (2010)

Role and Regulation of Glutathione Metabolism in Plasmodium falciparum
por: Müller, Sylke
Publicado: (2015)

Plasmodium falciparum glutamate dehydrogenase a is dispensable and not a drug target during erythrocytic development
por: Storm, Janet, et al.
Publicado: (2011)

Apicoplast Lipoic Acid Protein Ligase B Is Not Essential for Plasmodium falciparum
por: Günther, Svenja, et al.
Publicado: (2007)

The phenotype of a Plasmodium falciparum phosphoeno/pyruvate carboxylase null mutant
por: Storm, Janet, et al.
Publicado: (2010)

Glutathione mediated regulation of oligomeric structure and functional activity of Plasmodium falciparum glutathione S-transferase
por: Tripathi, Timir, et al.
Publicado: (2007)

Amodiaquine failure associated with erythrocytic glutathione in Plasmodium falciparum malaria
por: Zuluaga, Lina, et al.
Publicado: (2007)

Biochemical and structural characterization of the apicoplast dihydrolipoamide dehydrogenase of Plasmodium falciparum
por: Laine, Larissa M., et al.
Publicado: (2015)

Development of a Transgenic Plasmodium berghei Line (Pb(pfpkg)) Expressing the P. falciparum cGMP-Dependent Protein Kinase, a Novel Antimalarial Drug Target
por: Tewari, Rita, et al.
Publicado: (2014)

Inherited Glutathione Reductase Deficiency and Plasmodium falciparum Malaria—A Case Study
por: Gallo, Valentina, et al.
Publicado: (2009)

Role of glutathione biosynthesis in endothelial dysfunction and fibrosis
por: Espinosa-Díez, Cristina, et al.
Publicado: (2017)

Phosphoenolpyruvate Carboxylase Identified as a Key Enzyme in Erythrocytic Plasmodium falciparum Carbon Metabolism
por: Storm, Janet, et al.
Publicado: (2014)

The Plasmodium falciparum, Nima-related kinase Pfnek-4: a marker for asexual parasites committed to sexual differentiation
por: Reininger, Luc, et al.
Publicado: (2012)

Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle
por: Collins, Christine R, et al.
Publicado: (2013)

Real-Time Imaging of the Intracellular Glutathione Redox Potential in the Malaria Parasite Plasmodium falciparum
por: Kasozi, Denis, et al.
Publicado: (2013)

Structural and biochemical characterization of a mitochondrial peroxiredoxin from Plasmodium falciparum
por: Boucher, Ian W, et al.
Publicado: (2006)

Metabolomics profiling reveals new aspects of dolichol biosynthesis in Plasmodium falciparum
por: Zimbres, Flavia M., et al.
Publicado: (2020)

Association of reduced glutathione levels with Plasmodium falciparum and Plasmodium vivax malaria: a systematic review and meta-analysis
por: Kotepui, Manas, et al.
Publicado: (2023)

Compounds targeting GPI biosynthesis or N-glycosylation are active against Plasmodium falciparum
por: Fenollar, Àngel, et al.
Publicado: (2022)

Inactivation of Plasmodium falciparum in whole blood using the amustaline and glutathione pathogen reduction technology
por: Sow, Cissé, et al.
Publicado: (2020)

Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte
por: Riglar, David, et al.
Publicado: (2010)

Stepwise dissection of Plasmodium falciparum merozoite invasion of the human erythrocyte
por: Riglar, David, et al.
Publicado: (2010)

A Genome-wide Chromatin-associated Nuclear Peroxiredoxin from the Malaria Parasite Plasmodium falciparum
por: Richard, Dave, et al.
Publicado: (2011)

An improved single-step lysis protocol to measure luciferase bioluminescence in Plasmodium falciparum
por: Hasenkamp, Sandra, et al.
Publicado: (2012)

Metabolic dependency of chorismate in Plasmodium falciparum suggests an alternative source for the ubiquinone biosynthesis precursor
por: Valenciano, Ana Lisa, et al.
Publicado: (2019)

Characterization of the glutathione‐dependent reduction of the peroxiredoxin 5 homolog PfAOP from Plasmodium falciparum
por: Schumann, Robin, et al.
Publicado: (2022)

Biosynthesis of heme O in intraerythrocytic stages of Plasmodium falciparum and potential inhibitors of this pathway
por: Simão-Gurge, Raquel M., et al.
Publicado: (2019)

Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase
por: Marozienė, Audronė, et al.
Publicado: (2019)

The catalytic role of glutathione transferases in heterologous anthocyanin biosynthesis
por: Eichenberger, Michael, et al.
Publicado: (2023)

Robust inactivation of Plasmodium falciparum in red blood cell concentrates using amustaline and glutathione pathogen reduction
por: Sow, Cissé, et al.
Publicado: (2022)

Exploring the impact of glutathione S-transferase (GST)-based metabolic resistance to insecticide on vector competence of Anopheles funestus for Plasmodium falciparum
por: Ndo, Cyrille, et al.
Publicado: (2019)

Dissection of the Role of PfEMP1 and ICAM-1 in the Sensing of Plasmodium falciparum-Infected Erythrocytes by Natural Killer Cells
por: Baratin, Myriam, et al.
Publicado: (2007)

Electrophiles modulate glutathione reductase activity via alkylation and upregulation of glutathione biosynthesis
por: Jobbagy, Soma, et al.
Publicado: (2018)

Dissecting the Gene Expression, Localization, Membrane Topology, and Function of the Plasmodium falciparum STEVOR Protein Family
por: Wichers, J. Stephan, et al.
Publicado: (2019)

Lipoic Acid Metabolism of Plasmodium - A Suitable Drug Target
por: Storm, Janet, et al.
Publicado: (2012)

Knockout Studies Reveal an Important Role of Plasmodium Lipoic Acid Protein Ligase A1 for Asexual Blood Stage Parasite Survival
por: Günther, Svenja, et al.
Publicado: (2009)

Validation of Plasmodium falciparum dUTPase as the target of 5′-tritylated deoxyuridine analogues with anti-malarial activity
por: Pérez-Moreno, Guiomar, et al.
Publicado: (2019)

The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum
por: Bozdech, Zbynek, et al.
Publicado: (2003)

Telomeric Heterochromatin in Plasmodium falciparum
por: Hernandez-Rivas, Rosaura, et al.
Publicado: (2010)

Chemical genetics of Plasmodium falciparum
por: Guiguemde, W. Armand, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_5jke5avsevaaudqkqd17qatf4t