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Sarcopenia: A Major Challenge in Elderly Patients with End-Stage Renal Disease

Sarcopenia is a condition of multifaceted etiology arising in many elderly people. In patients with chronic kidney, the loss of muscle mass is much more intensive and the first signs of sarcopenia are observed in younger patients than it is expected. It is associated with the whole-body protein-ener...

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Detalles Bibliográficos
Autores principales: Domański, Maciej, Ciechanowski, Kazimierz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321443/
https://www.ncbi.nlm.nih.gov/pubmed/22536505
http://dx.doi.org/10.1155/2012/754739
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author Domański, Maciej
Ciechanowski, Kazimierz
author_facet Domański, Maciej
Ciechanowski, Kazimierz
author_sort Domański, Maciej
collection PubMed
description Sarcopenia is a condition of multifaceted etiology arising in many elderly people. In patients with chronic kidney, the loss of muscle mass is much more intensive and the first signs of sarcopenia are observed in younger patients than it is expected. It is associated with the whole-body protein-energy deficiency called protein-energy wasting (PEW). It seems to be one of the major factors limiting patient's autonomy as well as decreasing the quality of life. If it cannot be treated with the simple methods requiring some knowledge and devotion, we will fail to save patients who die due to cardiovascular disease and infection, despite proper conduction of renal replacement therapy. Many factors influencing the risk of sarcopenia development have been evaluated in number of studies. Many studies also were conducted to assess the efficacy of different therapeutic strategies (diet, physical activity, hormones). Nevertheless, there is still no consensus on treatment the patients with PEW. Therefore, in the paper we present the reasons and pathophysiology of sarcopenia as an important element of protein energy wasting (PEW) in elderly patients suffering from chronic kidney disease. We also analyze possible options for treatment according to up-to-date knowledge.
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spelling pubmed-33214432012-04-25 Sarcopenia: A Major Challenge in Elderly Patients with End-Stage Renal Disease Domański, Maciej Ciechanowski, Kazimierz J Aging Res Review Article Sarcopenia is a condition of multifaceted etiology arising in many elderly people. In patients with chronic kidney, the loss of muscle mass is much more intensive and the first signs of sarcopenia are observed in younger patients than it is expected. It is associated with the whole-body protein-energy deficiency called protein-energy wasting (PEW). It seems to be one of the major factors limiting patient's autonomy as well as decreasing the quality of life. If it cannot be treated with the simple methods requiring some knowledge and devotion, we will fail to save patients who die due to cardiovascular disease and infection, despite proper conduction of renal replacement therapy. Many factors influencing the risk of sarcopenia development have been evaluated in number of studies. Many studies also were conducted to assess the efficacy of different therapeutic strategies (diet, physical activity, hormones). Nevertheless, there is still no consensus on treatment the patients with PEW. Therefore, in the paper we present the reasons and pathophysiology of sarcopenia as an important element of protein energy wasting (PEW) in elderly patients suffering from chronic kidney disease. We also analyze possible options for treatment according to up-to-date knowledge. Hindawi Publishing Corporation 2012 2012-03-28 /pmc/articles/PMC3321443/ /pubmed/22536505 http://dx.doi.org/10.1155/2012/754739 Text en Copyright © 2012 M. Domański and K. Ciechanowski. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Domański, Maciej
Ciechanowski, Kazimierz
Sarcopenia: A Major Challenge in Elderly Patients with End-Stage Renal Disease
title Sarcopenia: A Major Challenge in Elderly Patients with End-Stage Renal Disease
title_full Sarcopenia: A Major Challenge in Elderly Patients with End-Stage Renal Disease
title_fullStr Sarcopenia: A Major Challenge in Elderly Patients with End-Stage Renal Disease
title_full_unstemmed Sarcopenia: A Major Challenge in Elderly Patients with End-Stage Renal Disease
title_short Sarcopenia: A Major Challenge in Elderly Patients with End-Stage Renal Disease
title_sort sarcopenia: a major challenge in elderly patients with end-stage renal disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321443/
https://www.ncbi.nlm.nih.gov/pubmed/22536505
http://dx.doi.org/10.1155/2012/754739
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