Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo

Rhabdomyosarcoma (RMS) is a paediatric soft-tissue sarcoma arising from skeletal muscle precursors coexpressing markers of proliferation and differentiation. Inducers of myogenic differentiation suppress RMS tumourigenic phenotype. The Notch target gene HES1 is upregulated in RMS and prevents tumour...

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Detalles Bibliográficos
Autores principales: Raimondi, L, Ciarapica, R, De Salvo, M, Verginelli, F, Gueguen, M, Martini, C, De Sio, L, Cortese, G, Locatelli, M, Dang, T P, Carlesso, N, Miele, L, Stifani, S, Limon, I, Locatelli, F, Rota, R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321627/
https://www.ncbi.nlm.nih.gov/pubmed/22117196
http://dx.doi.org/10.1038/cdd.2011.171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321627/
https://www.ncbi.nlm.nih.gov/pubmed/22117196
http://dx.doi.org/10.1038/cdd.2011.171

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