The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity

Hypoxic and oxidant stresses can coexist in biological systems, and oxidant stress has been proposed to activate hypoxia pathways through the inactivation of the ‘oxygen-sensing’ hypoxia-inducible factor (HIF) prolyl and asparaginyl hydroxylases. Here, we show that despite reduced sensitivity to cel...

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Detalles Bibliográficos
Autores principales: Masson, Norma, Singleton, Rachelle S, Sekirnik, Rok, Trudgian, David C, Ambrose, Lucy J, Miranda, Melroy X, Tian, Ya-Min, Kessler, Benedikt M, Schofield, Christopher J, Ratcliffe, Peter J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Molecular Biology Organization 2012
Materias:
Scientific Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323130/
https://www.ncbi.nlm.nih.gov/pubmed/22310300
http://dx.doi.org/10.1038/embor.2012.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323130/
https://www.ncbi.nlm.nih.gov/pubmed/22310300
http://dx.doi.org/10.1038/embor.2012.9

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