Direct Ubiquitin Independent Recognition and Degradation of a Folded Protein by the Eukaryotic Proteasomes-Origin of Intrinsic Degradation Signals

Eukaryotic 26S proteasomes are structurally organized to recognize, unfold and degrade globular proteins. However, all existing model substrates of the 26S proteasome in addition to ubiquitin or adaptor proteins require unstructured regions in the form of fusion tags for efficient degradation. We re...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh Gautam, Amit Kumar, Balakrishnan, Satish, Venkatraman, Prasanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323579/
https://www.ncbi.nlm.nih.gov/pubmed/22506054
http://dx.doi.org/10.1371/journal.pone.0034864

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323579/
https://www.ncbi.nlm.nih.gov/pubmed/22506054
http://dx.doi.org/10.1371/journal.pone.0034864

Ejemplares similares