Genetics of Clusterin Isoform Expression and Alzheimer's Disease Risk

The minor allele of rs11136000 within CLU is strongly associated with reduced Alzheimer's disease (AD) risk. The mechanism underlying this association is unclear. Here, we report that CLU1 and CLU2 are the two primary CLU isoforms in human brain; CLU1 and CLU2 share exons 2–9 but differ in exon...

Descripción completa

Detalles Bibliográficos
Autores principales: Ling, I-Fang, Bhongsatiern, Jiraganya, Simpson, James F., Fardo, David W., Estus, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323613/
https://www.ncbi.nlm.nih.gov/pubmed/22506010
http://dx.doi.org/10.1371/journal.pone.0033923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323613/
https://www.ncbi.nlm.nih.gov/pubmed/22506010
http://dx.doi.org/10.1371/journal.pone.0033923

Ejemplares similares