B-RAF Mutant Alleles Associated with Langerhans Cell Histiocytosis, a Granulomatous Pediatric Disease

BACKGROUND: Langerhans cell histiocytosis (LCH) features inflammatory granuloma characterised by the presence of CD1a+ dendritic cells or ‘LCH cells’. Badalian-Very et al. recently reported the presence of a canonical (V600E)B-RAF mutation in 57% of paraffin-embedded biopsies from LCH granuloma. Her...

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Detalles Bibliográficos
Autores principales: Satoh, Takeshi, Smith, Alexander, Sarde, Aurelien, Lu, Hui-chun, Mian, Sophie, Trouillet, Celine, Mufti, Ghulam, Emile, Jean-Francois, Fraternali, Franca, Donadieu, Jean, Geissmann, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323620/
https://www.ncbi.nlm.nih.gov/pubmed/22506009
http://dx.doi.org/10.1371/journal.pone.0033891

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323620/
https://www.ncbi.nlm.nih.gov/pubmed/22506009
http://dx.doi.org/10.1371/journal.pone.0033891

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