Versatility of Cooperative Transcriptional Activation: A Thermodynamical Modeling Analysis for Greater-Than-Additive and Less-Than-Additive Effects

We derive a statistical model of transcriptional activation using equilibrium thermodynamics of chemical reactions. We examine to what extent this statistical model predicts synergy effects of cooperative activation of gene expression. We determine parameter domains in which greater-than-additive an...

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Detalles Bibliográficos
Autores principales: Frank, Till D., Carmody, Aimée M., Kholodenko, Boris N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323628/
https://www.ncbi.nlm.nih.gov/pubmed/22506020
http://dx.doi.org/10.1371/journal.pone.0034439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3323628/
https://www.ncbi.nlm.nih.gov/pubmed/22506020
http://dx.doi.org/10.1371/journal.pone.0034439

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