Cargando…

NGF promotes cell cycle progression by regulating D-type cyclins via PI3K/Akt and MAPK/Erk activation in human corneal epithelial cells

PURPOSE: Nerve growth factor (NGF) plays an important role in promoting the healing of corneal wounds. However, the molecular mechanism by which NGF functions is unknown. We investigated the possible effects of NGF on phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) and mitogen activated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hong, Jiaxu, Qian, Tingting, Le, Qihua, Sun, Xinghuai, Wu, Jihong, Chen, Junyi, Yu, Xiaobo, Xu, Jianjiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Vision 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324366/ https://www.ncbi.nlm.nih.gov/pubmed/22509106

Ejemplares similares

Heightened expression of MICA enhances the cytotoxicity of NK cells or CD8(+)T cells to human corneal epithelium in vitro
por: Hong, Jiaxu, et al.
Publicado: (2012)

Comparison of human corneal cell density by age and corneal location: an in vivo confocal microscopy study
por: Zheng, Tianyu, et al.
Publicado: (2016)

Age-Related Changes in Human Schlemm’s Canal: An in Vivo Optical Coherence Tomography-Based Study
por: Zhao, Yujin, et al.
Publicado: (2018)

NGF and NGF-receptor expression of cultured immortalized human corneal endothelial cells
por: Sornelli, Federica, et al.
Publicado: (2010)

ProNGF/NGF Modulates Autophagy and Apoptosis through PI3K/Akt/mTOR and ERK Signaling Pathways following Cerebral Ischemia-Reperfusion in Rats
por: Li, Yanbo, et al.
Publicado: (2022)

Analysis of medical expenditure and socio-economic status in patients with ocular chemical burns in East China: a retrospective study
por: Le, Qihua, et al.
Publicado: (2012)

Effects of evodiamine on PI3K/Akt and MAPK/ERK signaling pathways in pancreatic cancer cells
por: Hong, Zhong, et al.
Publicado: (2020)

NGF increases VEGF expression and promotes cell proliferation via ERK1/2 and AKT signaling in Müller cells
por: Wang, Jing, et al.
Publicado: (2016)

Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71
por: Wong, Wen-Rou, et al.
Publicado: (2005)

Lysophosphatidylcholine enhances NGF-induced MAPK and Akt signals through the extracellular domain of TrkA in PC12 cells()
por: Wuhanqimuge, et al.
Publicado: (2013)

Simvastatin-induced breast cancer cell death and deactivation of PI3K/Akt and MAPK/ERK signalling are reversed by metabolic products of the mevalonate pathway
por: Wang, Tingting, et al.
Publicado: (2015)

NGF Accelerates Cutaneous Wound Healing by Promoting the Migration of Dermal Fibroblasts via the PI3K/Akt-Rac1-JNK and ERK Pathways
por: Chen, Ji-Cai, et al.
Publicado: (2014)

The Roles of PI3K/AKT/mTOR and MAPK/ERK Signaling Pathways in Human Pheochromocytomas
por: Du, Juan, et al.
Publicado: (2016)

Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
por: Roy, Sanjit K, et al.
Publicado: (2010)

Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line
por: Lee, Yong Yook, et al.
Publicado: (2013)

Apocynin and Diphenyleneiodonium Induce Oxidative Stress and Modulate PI3K/Akt and MAPK/Erk Activity in Mouse Embryonic Stem Cells
por: Kučera, Jan, et al.
Publicado: (2016)

Ginsenoside-Rd Promotes Neurite Outgrowth of PC12 Cells through MAPK/ERK- and PI3K/AKT-Dependent Pathways
por: Wu, Song-Di, et al.
Publicado: (2016)

ERK/MAPK and PI3K/AKT signal channels simultaneously activated in nerve cell and axon after facial nerve injury
por: Huang, Hai-tao, et al.
Publicado: (2017)

ENKUR acts as a tumor suppressor in lung adenocarcinoma cells through PI3K/Akt and MAPK/ERK signaling pathways
por: Ma, Qing, et al.
Publicado: (2019)

Characteristics of the PI3K/AKT and MAPK/ERK pathways involved in the maintenance of self-renewal in lung cancer stem-like cells
por: Li, Jingyuan, et al.
Publicado: (2021)

Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion
por: Zhou, Jing, et al.
Publicado: (2015)

Cannabidiol‐mediated RISK PI3K/AKT and MAPK/ERK pathways decreasing reperfusion myocardial damage
por: Franco‐Vadillo, Antonio, et al.
Publicado: (2021)

Adipose Mesenchymal Stromal Cell-Derived Exosomes Prevent Testicular Torsion Injury via Activating PI3K/AKT and MAPK/ERK1/2 Pathways
por: Liu, Hengchen, et al.
Publicado: (2022)

RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK–cyclin D1/CDK4 pathway
por: Wang, Suihai, et al.
Publicado: (2019)

HBx Protein Promotes Oval Cell Proliferation by Up-Regulation of Cyclin D1 via Activation of the MEK/ERK and PI3K/Akt Pathways
por: Wang, Heng-Yi, et al.
Publicado: (2014)

Inhibitory effects of delphinidin on the proliferation of ovarian cancer cells via PI3K/AKT and ERK 1/2 MAPK signal transduction
por: Lim, Whasun, et al.
Publicado: (2017)

The Nutritional Cytokine Leptin Promotes NSCLC by Activating the PI3K/AKT and MAPK/ERK Pathways in NSCLC Cells in a Paracrine Manner
por: Li, Fengzhou, et al.
Publicado: (2019)

Erianin suppresses hepatocellular carcinoma cells through down-regulation of PI3K/AKT, p38 and ERK MAPK signaling pathways
por: Yang, Liang, et al.
Publicado: (2020)

Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways Affects NRF2, Trx and GSH Antioxidant Systems in Leukemia Cells
por: Jasek-Gajda, Ewa, et al.
Publicado: (2020)

7,8-Dihydroxiflavone Protects Adult Rat Axotomized Retinal Ganglion Cells through MAPK/ERK and PI3K/AKT Activation
por: Galindo-Romero, Caridad, et al.
Publicado: (2021)

Hesperetin Inhibits Vascular Formation by Suppressing of the PI3K/AKT, ERK, and p38 MAPK Signaling Pathways
por: Kim, Gi Dae
Publicado: (2014)

Gomisin N Inhibits Melanogenesis through Regulating the PI3K/Akt and MAPK/ERK Signaling Pathways in Melanocytes
por: Chae, Jae Kyoung, et al.
Publicado: (2017)

The relationship between corneal biomechanical parameters and treatment outcomes of orthokeratology lenses
por: Li, Xia, et al.
Publicado: (2022)

Concanavalin A promotes angiogenesis and proliferation in endothelial cells through the Akt/ERK/Cyclin D1 axis
por: Li, Jing-Zhou, et al.
Publicado: (2021)

Biphasic Regulation of Caveolin-1 Gene Expression by Fluoxetine in Astrocytes: Opposite Effects of PI3K/AKT and MAPK/ERK Signaling Pathways on c-fos
por: Li, Baoman, et al.
Publicado: (2017)

NGF from pancreatic stellate cells induces pancreatic cancer proliferation and invasion by PI3K/AKT/GSK signal pathway
por: Jiang, Jie, et al.
Publicado: (2020)

Sorafenib Inhibits Lymphoma Xenografts by Targeting MAPK/ERK and AKT Pathways in Tumor and Vascular Cells
por: Carlo-Stella, Carmelo, et al.
Publicado: (2013)

Leptin Induces Cyclin D1 Expression and Proliferation of Human Nucleus Pulposus Cells via JAK/STAT, PI3K/Akt and MEK/ERK Pathways
por: Li, Zheng, et al.
Publicado: (2012)

Biphasic activation of PI3K/Akt and MAPK/Erk1/2 signaling pathways in bovine herpesvirus type 1 infection of MDBK cells
por: Zhu, Liqian, et al.
Publicado: (2011)

ETV2 promotes osteogenic differentiation of human dental pulp stem cells through the ERK/MAPK and PI3K-Akt signaling pathways
por: Li, Jing, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1p58ccqmdf0ufv2f9kqsbj0i3p