Regulation of Progranulin Expression in Human Microglia and Proteolysis of Progranulin by Matrix Metalloproteinase-12 (MMP-12)

BACKGROUND: The essential role of progranulin (PGRN) as a neurotrophic factor has been demonstrated by the discovery that haploinsufficiency due to GRN gene mutations causes frontotemporal lobar dementia. In addition to neurons, microglia in vivo express PGRN, but little is known about the regulatio...

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Detalles Bibliográficos
Autores principales: Suh, Hyeon-Sook, Choi, Namjong, Tarassishin, Leonid, Lee, Sunhee C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324426/
https://www.ncbi.nlm.nih.gov/pubmed/22509390
http://dx.doi.org/10.1371/journal.pone.0035115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324426/
https://www.ncbi.nlm.nih.gov/pubmed/22509390
http://dx.doi.org/10.1371/journal.pone.0035115

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