PORCN Moonlights in a Wnt-Independent Pathway That Regulates Cancer Cell Proliferation

Porcupine (PORCN) is a membrane-bound O-acyl transferase that is required for the palmitoylation of Wnt proteins, and that is essential in diverse Wnt pathways for Wnt-Wntless (WLS) binding, Wnt secretion, and Wnt signaling activity. We tested if PORCN was required for the proliferation of transform...

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Detalles Bibliográficos
Autores principales: Covey, Tracy M., Kaur, Simran, Tan Ong, Tina, Proffitt, Kyle D., Wu, Yonghui, Tan, Patrick, Virshup, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324524/
https://www.ncbi.nlm.nih.gov/pubmed/22509316
http://dx.doi.org/10.1371/journal.pone.0034532

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324524/
https://www.ncbi.nlm.nih.gov/pubmed/22509316
http://dx.doi.org/10.1371/journal.pone.0034532

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