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Dimer Formation Enhances Structural Differences between Amyloid β-Protein (1–40) and (1–42): An Explicit-Solvent Molecular Dynamics Study
Amyloid [Image: see text]-protein (A[Image: see text]) is central to the pathology of Alzheimer's disease. A 5% difference in the primary structure of the two predominant alloforms, A[Image: see text] and A[Image: see text], results in distinct assembly pathways and toxicity properties. Discret...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324527/ https://www.ncbi.nlm.nih.gov/pubmed/22509291 http://dx.doi.org/10.1371/journal.pone.0034345 |