Regulation of p53 Stability and Apoptosis by a ROR Agonist

Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that...

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Detalles Bibliográficos
Autores principales: Wang, Yongjun, Solt, Laura A., Kojetin, Douglas J., Burris, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324542/
https://www.ncbi.nlm.nih.gov/pubmed/22509368
http://dx.doi.org/10.1371/journal.pone.0034921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324542/
https://www.ncbi.nlm.nih.gov/pubmed/22509368
http://dx.doi.org/10.1371/journal.pone.0034921

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