Regulation of p53 Stability and Apoptosis by a ROR Agonist

Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that...

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Detalles Bibliográficos
Autores principales: Wang, Yongjun, Solt, Laura A., Kojetin, Douglas J., Burris, Thomas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324542/
https://www.ncbi.nlm.nih.gov/pubmed/22509368
http://dx.doi.org/10.1371/journal.pone.0034921
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author Wang, Yongjun
Solt, Laura A.
Kojetin, Douglas J.
Burris, Thomas P.
author_facet Wang, Yongjun
Solt, Laura A.
Kojetin, Douglas J.
Burris, Thomas P.
author_sort Wang, Yongjun
collection PubMed
description Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer.
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spelling pubmed-33245422012-04-16 Regulation of p53 Stability and Apoptosis by a ROR Agonist Wang, Yongjun Solt, Laura A. Kojetin, Douglas J. Burris, Thomas P. PLoS One Research Article Activation of p53 function leading to cell-cycle arrest and/or apoptosis is a promising strategy for development of anti-cancer therapeutic agents. Here, we describe a novel mechanism for stabilization of p53 protein expression via activation of the orphan nuclear receptor, RORα. We demonstrate that treatment of cancer cells with a newly described synthetic ROR agonist, SR1078, leads to p53 stabilization and induction of apoptosis. These data suggest that synthetic ROR agonists may hold utility in the treatment of cancer. Public Library of Science 2012-04-11 /pmc/articles/PMC3324542/ /pubmed/22509368 http://dx.doi.org/10.1371/journal.pone.0034921 Text en Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wang, Yongjun
Solt, Laura A.
Kojetin, Douglas J.
Burris, Thomas P.
Regulation of p53 Stability and Apoptosis by a ROR Agonist
title Regulation of p53 Stability and Apoptosis by a ROR Agonist
title_full Regulation of p53 Stability and Apoptosis by a ROR Agonist
title_fullStr Regulation of p53 Stability and Apoptosis by a ROR Agonist
title_full_unstemmed Regulation of p53 Stability and Apoptosis by a ROR Agonist
title_short Regulation of p53 Stability and Apoptosis by a ROR Agonist
title_sort regulation of p53 stability and apoptosis by a ror agonist
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324542/
https://www.ncbi.nlm.nih.gov/pubmed/22509368
http://dx.doi.org/10.1371/journal.pone.0034921
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