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Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Gene expression actualizes the organismal phenotypes encoded within the genome in an environment-dependent manner. Among all encoded phenotypes, cell population growth rate (fitness) is perhaps the most important, since it determines how well-adapted a genotype is in various environments. Traditiona...

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Detalles Bibliográficos
Autores principales: Nevozhay, Dmitry, Adams, Rhys M., Van Itallie, Elizabeth, Bennett, Matthew R., Balázsi, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325171/
https://www.ncbi.nlm.nih.gov/pubmed/22511863
http://dx.doi.org/10.1371/journal.pcbi.1002480