Role of Active Site Rigidity in Activity: MD Simulation and Fluorescence Study on a Lipase Mutant

Relationship between stability and activity of enzymes is maintained by underlying conformational flexibility. In thermophilic enzymes, a decrease in flexibility causes low enzyme activity while in less stable proteins such as mesophiles and psychrophiles, an increase in flexibility is associated wi...

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Detalles Bibliográficos
Autores principales: Kamal, Md. Zahid, Mohammad, Tabrez Anwar Shamim, Krishnamoorthy, G., Rao, Nalam Madhusudhana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325981/
https://www.ncbi.nlm.nih.gov/pubmed/22514720
http://dx.doi.org/10.1371/journal.pone.0035188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325981/
https://www.ncbi.nlm.nih.gov/pubmed/22514720
http://dx.doi.org/10.1371/journal.pone.0035188

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