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Role of Active Site Rigidity in Activity: MD Simulation and Fluorescence Study on a Lipase Mutant
Relationship between stability and activity of enzymes is maintained by underlying conformational flexibility. In thermophilic enzymes, a decrease in flexibility causes low enzyme activity while in less stable proteins such as mesophiles and psychrophiles, an increase in flexibility is associated wi...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325981/ https://www.ncbi.nlm.nih.gov/pubmed/22514720 http://dx.doi.org/10.1371/journal.pone.0035188 |