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Role of Misfolded N-CoR Mediated Transcriptional Deregulation of Flt3 in Acute Monocytic Leukemia (AML)-M5 Subtype
The nuclear receptor co-repressor (N-CoR) is a key component of the generic multi-protein complex involved in transcriptional control. Flt3, a key regulator of hematopoietic cell growth, is frequently deregulated in AML (acute myeloid leukemia). Here, we report that loss of N-CoR-mediated transcript...
Autores principales: | Nin, Dawn Sijin, Kok, Wai Kay, Li, Feng, Takahashi, Shinichiro, Chng, Wee Joo, Khan, Matiullah |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326026/ https://www.ncbi.nlm.nih.gov/pubmed/22514634 http://dx.doi.org/10.1371/journal.pone.0034501 |
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