Telomerase RNA biogenesis involves sequential binding by Sm and Lsm complexes

In most eukaryotes, the progressive loss of chromosome-terminal DNA sequences is counteracted by the enzyme telomerase, a reverse transcriptase that uses part of an RNA subunit as template to synthesize telomeric repeats. Many cancer cells express high telomerase activity and mutations in telomerase...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Wen, Kannan, Ram, Blanchette, Marco, Baumann, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326189/
https://www.ncbi.nlm.nih.gov/pubmed/22446625
http://dx.doi.org/10.1038/nature10924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326189/
https://www.ncbi.nlm.nih.gov/pubmed/22446625
http://dx.doi.org/10.1038/nature10924

Ejemplares similares