Keratin 16 null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders

Keratin 16 (KRT16 in human, Krt16 in mouse), a type I intermediate filament protein, is constitutively expressed in epithelial appendages and is induced in the epidermis upon wounding and other stressors. Mutations altering the coding sequence of KRT16 cause Pachyonychia Congenita (PC), a rare autos...

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Detalles Bibliográficos
Autores principales: Lessard, Juliane C., Coulombe, Pierre A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326191/
https://www.ncbi.nlm.nih.gov/pubmed/22336941
http://dx.doi.org/10.1038/jid.2012.6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326191/
https://www.ncbi.nlm.nih.gov/pubmed/22336941
http://dx.doi.org/10.1038/jid.2012.6

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