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Keratin 16 null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders
Keratin 16 (KRT16 in human, Krt16 in mouse), a type I intermediate filament protein, is constitutively expressed in epithelial appendages and is induced in the epidermis upon wounding and other stressors. Mutations altering the coding sequence of KRT16 cause Pachyonychia Congenita (PC), a rare autos...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326191/ https://www.ncbi.nlm.nih.gov/pubmed/22336941 http://dx.doi.org/10.1038/jid.2012.6 |