Brk/PTK6 Sustains Activated EGFR Signaling through Inhibiting EGFR Degradation and Transactivating EGFR

Epidermal growth factor receptor (EGFR)-mediated cell signaling is critical for mammary epithelial cell growth and survival; however, targeting EGFR has shown no or only minimal therapeutic benefit in patients with breast cancer. Here, we report a novel regulatory mechanism of EGFR signaling that ma...

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Detalles Bibliográficos
Autores principales: Li, X, Lu, Y, Liang, K, Hsu, J -M., Albarracin, C, Mills, G B, Hung, M-C, Fan, Z
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326223/
https://www.ncbi.nlm.nih.gov/pubmed/22231447
http://dx.doi.org/10.1038/onc.2011.608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326223/
https://www.ncbi.nlm.nih.gov/pubmed/22231447
http://dx.doi.org/10.1038/onc.2011.608

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