Structure of Musashi1 in a complex with target RNA: the role of aromatic stacking interactions

Mammalian Musashi1 (Msi1) is an RNA-binding protein that regulates the translation of target mRNAs, and participates in the maintenance of cell ‘stemness’ and tumorigenesis. Msi1 reportedly binds to the 3′-untranslated region of mRNA of Numb, which encodes Notch inhibitor, and impedes initiation of...

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Detalles Bibliográficos
Autores principales: Ohyama, Takako, Nagata, Takashi, Tsuda, Kengo, Kobayashi, Naohiro, Imai, Takao, Okano, Hideyuki, Yamazaki, Toshio, Katahira, Masato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326303/
https://www.ncbi.nlm.nih.gov/pubmed/22140116
http://dx.doi.org/10.1093/nar/gkr1139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326303/
https://www.ncbi.nlm.nih.gov/pubmed/22140116
http://dx.doi.org/10.1093/nar/gkr1139

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