New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats

Myotonic Dystrophy type I (DM1) is caused by an abnormal expansion of CTG triplets in the 3′ UTR of the dystrophia myotonica protein kinase (DMPK) gene, leading to the aggregation of the mutant transcript in nuclear RNA foci. The expanded mutant transcript promotes the sequestration of the MBNL1 spl...

Descripción completa

Detalles Bibliográficos
Autores principales: Laurent, François-Xavier, Sureau, Alain, Klein, Arnaud F., Trouslard, François, Gasnier, Erwan, Furling, Denis, Marie, Joëlle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326330/
https://www.ncbi.nlm.nih.gov/pubmed/22156369
http://dx.doi.org/10.1093/nar/gkr1228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326330/
https://www.ncbi.nlm.nih.gov/pubmed/22156369
http://dx.doi.org/10.1093/nar/gkr1228

Ejemplares similares