Variants on the promoter region of PTEN affect breast cancer progression and patient survival

INTRODUCTION: The PTEN gene, a regulator of the phosphatidylinositol-3-kinase (PI3K)/Akt oncogenic pathway, is mutated in various cancers and its expression has been associated with tumor progression in a dose-dependent fashion. We investigated the effect of germline variation in the promoter region...

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Detalles Bibliográficos
Autores principales: Heikkinen, Tuomas, Greco, Dario, Pelttari, Liisa M, Tommiska, Johanna, Vahteristo, Pia, Heikkilä, Päivi, Blomqvist, Carl, Aittomäki, Kristiina, Nevanlinna, Heli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326572/
https://www.ncbi.nlm.nih.gov/pubmed/22171747
http://dx.doi.org/10.1186/bcr3076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326572/
https://www.ncbi.nlm.nih.gov/pubmed/22171747
http://dx.doi.org/10.1186/bcr3076

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