Structure–Activity Relationships, Ligand Efficiency, and Lipophilic Efficiency Profiles of Benzophenone-Type Inhibitors of the Multidrug Transporter P-Glycoprotein

[Image: see text] The drug efflux pump P-glycoprotein (P-gp) has been shown to promote multidrug resistance (MDR) in tumors as well as to influence ADME properties of drug candidates. Here we synthesized and tested a series of benzophenone derivatives structurally analogous to propafenone-type inhib...

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Detalles Bibliográficos
Autores principales: Jabeen, Ishrat, Pleban, Karin, Rinner, Uwe, Chiba, Peter, Ecker, Gerhard F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326594/
https://www.ncbi.nlm.nih.gov/pubmed/22452412
http://dx.doi.org/10.1021/jm201705f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326594/
https://www.ncbi.nlm.nih.gov/pubmed/22452412
http://dx.doi.org/10.1021/jm201705f

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