Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors

A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases. Compounds 12, 13 and 20 proved to be active against both insect and porcine trehalases with selectivity towards the insect glycosidase...

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Detalles Bibliográficos
Autores principales: Bini, Davide, Cardona, Francesca, Forcella, Matilde, Parmeggiani, Camilla, Parenti, Paolo, Nicotra, Francesco, Cipolla, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2012
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326631/
https://www.ncbi.nlm.nih.gov/pubmed/22509223
http://dx.doi.org/10.3762/bjoc.8.58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326631/
https://www.ncbi.nlm.nih.gov/pubmed/22509223
http://dx.doi.org/10.3762/bjoc.8.58

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