Reduced expression of MECP2 affects cell commitment and maintenance in neurons by triggering senescence: new perspective for Rett syndrome

MECP2 protein binds preferentially to methylated CpGs and regulates gene expression by causing changes in chromatin structure. The mechanism by which impaired MECP2 activity can induce pathological abnormalities in the nervous system of patients with Rett syndrome (RTT) is not clearly understood. To...

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Detalles Bibliográficos
Autores principales: Squillaro, Tiziana, Alessio, Nicola, Cipollaro, Marilena, Melone, Mariarosa Anna Beatrice, Hayek, Giuseppe, Renieri, Alessandra, Giordano, Antonio, Galderisi, Umberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327309/
https://www.ncbi.nlm.nih.gov/pubmed/22357617
http://dx.doi.org/10.1091/mbc.E11-09-0784

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327309/
https://www.ncbi.nlm.nih.gov/pubmed/22357617
http://dx.doi.org/10.1091/mbc.E11-09-0784

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