Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase

Gaucher disease is a lysosomal storage disorder caused by a defect in the degradation of glucosylceramide catalyzed by the lysosomal enzyme β-glucocerebrosidase (GBA). GBA reaches lysosomes via association with its receptor, lysosomal integral membrane protein type 2 (LIMP-2). We found that distinct...

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Detalles Bibliográficos
Autores principales: Jović, Marko, Kean, Michelle J., Szentpetery, Zsofia, Polevoy, Gordon, Gingras, Anne-Claude, Brill, Julie A., Balla, Tamas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327330/
https://www.ncbi.nlm.nih.gov/pubmed/22337770
http://dx.doi.org/10.1091/mbc.E11-06-0553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327330/
https://www.ncbi.nlm.nih.gov/pubmed/22337770
http://dx.doi.org/10.1091/mbc.E11-06-0553

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