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Two phosphatidylinositol 4-kinases control lysosomal delivery of the Gaucher disease enzyme, β-glucocerebrosidase
Gaucher disease is a lysosomal storage disorder caused by a defect in the degradation of glucosylceramide catalyzed by the lysosomal enzyme β-glucocerebrosidase (GBA). GBA reaches lysosomes via association with its receptor, lysosomal integral membrane protein type 2 (LIMP-2). We found that distinct...
Autores principales: | Jović, Marko, Kean, Michelle J., Szentpetery, Zsofia, Polevoy, Gordon, Gingras, Anne-Claude, Brill, Julie A., Balla, Tamas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327330/ https://www.ncbi.nlm.nih.gov/pubmed/22337770 http://dx.doi.org/10.1091/mbc.E11-06-0553 |
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