Inhibition of connective tissue growth factor by small interfering ribonucleic acid prevents increase in extracellular matrix molecules in a rodent model of diabetic retinopathy

PURPOSE: Connective tissue growth factor (CTGF) is a profibrotic factor that induces extracellular matrix (ECM) production and angiogenesis, two processes involved in diabetic retinopathy (DR). In this study, we examined whether insulin therapy or a CTGF-specific small interfering RNA (siRNA) admini...

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Detalles Bibliográficos
Autores principales: Winkler, Jennifer L., Kedees, Mamdouh H., Guz, Yelena, Teitelman, Gladys
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327439/
https://www.ncbi.nlm.nih.gov/pubmed/22511849

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327439/
https://www.ncbi.nlm.nih.gov/pubmed/22511849

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