Conserved phosphoryl transfer mechanisms within kinase families and the role of the C8 proton of ATP in the activation of phosphoryl transfer

BACKGROUND: The kinome is made up of a large number of functionally diverse enzymes, with the classification indicating very little about the extent of the conserved kinetic mechanisms associated with phosphoryl transfer. It has been demonstrated that C8-H of ATP plays a critical role in the activit...

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Detalles Bibliográficos
Autores principales: Kenyon, Colin P, Roth, Robyn L, van der Westhuyzen, Chris W, Parkinson, Christopher J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327638/
https://www.ncbi.nlm.nih.gov/pubmed/22397702
http://dx.doi.org/10.1186/1756-0500-5-131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327638/
https://www.ncbi.nlm.nih.gov/pubmed/22397702
http://dx.doi.org/10.1186/1756-0500-5-131

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