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Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus

The movement of proteins between the cytoplasm and nucleus mediated by the importin superfamily of proteins is essential to many cellular processes, including differentiation and development, and is critical to disease states such as viral disease and oncogenesis. We recently developed a high-throug...

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Detalles Bibliográficos
Autores principales: Wagstaff, Kylie M., Sivakumaran, Haran, Heaton, Steven M., Harrich, David, Jans, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3327999/
https://www.ncbi.nlm.nih.gov/pubmed/22417684
http://dx.doi.org/10.1042/BJ20120150