Radiosensitization by the novel DNA intercalating agent vosaroxin

PURPOSE: Vosaroxin is a first in class naphthyridine analog structurally related to quinolone antibacterials, that intercalates DNA and inhibits topoisomerase II. Vosaroxin is not a P-glycoprotein receptor substrate and its activity is independent of p53, thus evading common drug resistance mechanis...

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Detalles Bibliográficos
Autores principales: Gordon, Ira K, Graves, Christian, Kil, Whoon J, Kramp, Tamalee, Tofilon, Philip, Camphausen, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328287/
https://www.ncbi.nlm.nih.gov/pubmed/22369205
http://dx.doi.org/10.1186/1748-717X-7-26

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328287/
https://www.ncbi.nlm.nih.gov/pubmed/22369205
http://dx.doi.org/10.1186/1748-717X-7-26

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