Structural insight into MR1-mediated recognition of the mucosal associated invariant T cell receptor

Mucosal-associated invariant T (MAIT) cells express a semiinvariant αβ T cell receptor (TCR) that binds MHC class I–like molecule (MR1). However, the molecular basis for MAIT TCR recognition by MR1 is unknown. In this study, we present the crystal structure of a human Vα7.2Jα33-Vβ2 MAIT TCR. Mutagen...

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Detalles Bibliográficos
Autores principales: Reantragoon, Rangsima, Kjer-Nielsen, Lars, Patel, Onisha, Chen, Zhenjun, Illing, Patricia T., Bhati, Mugdha, Kostenko, Lyudmila, Bharadwaj, Mandvi, Meehan, Bronwyn, Hansen, Ted H., Godfrey, Dale I., Rossjohn, Jamie, McCluskey, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328369/
https://www.ncbi.nlm.nih.gov/pubmed/22412157
http://dx.doi.org/10.1084/jem.20112095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328369/
https://www.ncbi.nlm.nih.gov/pubmed/22412157
http://dx.doi.org/10.1084/jem.20112095

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