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Conformational States of a Bacterial α(2)-Macroglobulin Resemble Those of Human Complement C3
α(2) macroglobulins (α(2)Ms) are broad-spectrum protease inhibitors that play essential roles in the innate immune system of eukaryotic species. These large, multi-domain proteins are characterized by a broad-spectrum bait region and an internal thioester, which, upon cleavage, becomes covalently as...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328433/ https://www.ncbi.nlm.nih.gov/pubmed/22530012 http://dx.doi.org/10.1371/journal.pone.0035384 |