Rapamycin toxicity in MIN6 cells and rat and human islets is mediated by the inhibition of mTOR complex 2 (mTORC2)

AIMS/HYPOTHESIS: Rapamycin (sirolimus) is one of the primary immunosuppressants for islet transplantation. Yet there is evidence that the long-term treatment of islet-transplant patients with rapamycin may be responsible for subsequent loss of islet graft function and viability. Therefore, the prima...

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Detalles Bibliográficos
Autores principales: Barlow, A. D., Xie, J., Moore, C. E., Campbell, S. C., Shaw, J. A. M., Nicholson, M. L., Herbert, T. P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328678/
https://www.ncbi.nlm.nih.gov/pubmed/22314813
http://dx.doi.org/10.1007/s00125-012-2475-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328678/
https://www.ncbi.nlm.nih.gov/pubmed/22314813
http://dx.doi.org/10.1007/s00125-012-2475-7

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