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Allosteric Activation of the Phosphoinositide Phosphatase Sac1 by Anionic Phospholipids
[Image: see text] Sac family phosphoinositide phosphatases comprise an evolutionarily conserved family of enzymes in eukaryotes. Our recently determined crystal structure of the Sac phosphatase domain of yeast Sac1, the founding member of the Sac family proteins, revealed a unique conformation of th...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329130/ https://www.ncbi.nlm.nih.gov/pubmed/22452743 http://dx.doi.org/10.1021/bi300086c |