Differential Regulation of Cutaneous Oncoprotein HPVE6 by wtp53, Mutant p53R248W and ΔNp63α is HPV Type Dependent

UV exposure and p53 mutations are major factors in non-melanoma skin cancer, whereas a role for HPV infections has not been defined. Previous data demonstrated the wtp53-mediated degradation of cutaneous HPV20E6 by caspase-3. ΔNp63α and hot-spot mutant p53R248W conveyed a protective effect on HPV20E...

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Detalles Bibliográficos
Autores principales: Fei, Jian-Wei, de Villiers, Ethel-Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329482/
https://www.ncbi.nlm.nih.gov/pubmed/22530045
http://dx.doi.org/10.1371/journal.pone.0035540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3329482/
https://www.ncbi.nlm.nih.gov/pubmed/22530045
http://dx.doi.org/10.1371/journal.pone.0035540

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